Dr. Ernest Fraenkel, Massachusetts Institute of Technology
Prof. Fraenkel received his A.B. in Chemistry and Physics from Harvard College and his Ph.D. in Biology at the laboratory of Professor Carl Pabofrom at MIT. He continued his post-doctoral research as a fellow at the laboratory of Professor Stephen Harrison at Harvard University. He was a Whitehead Fellow and a Pfizer Computational Biology Fellow at the Whitehead Institute. Prof. Fraenkel joined MIT as a Research Affiliate at the MIT Computer Science and Artificial Intelligence Laboratory. He became an Assistant Professor at the Department of Biological Engineering in 2006. The Fraenkel laboratory is developing computational and experimental approaches to search for new therapeutic strategies for diseases. New experimental methods make it possible to measure cellular changes across the genome and proteome. These technologies include genome-wide measurements of transcription, of protein-DNA interactions (ChIP-Seq), of genetic interactions, and of protein modifications. Each data source provides a very narrow view of the cellular changes. However, by computationally integrating these data the group can reconstruct signaling pathways and identify previously unrecognized regulatory mechanisms that contribute to the etiology of disease and may provide new approaches for treatment.

Dr. Maria Martin, European Bioinformatics Institute (EMBL-EBI)
Maria’s team provides the bioinformatics infrastructure for the databases and services of the Universal Protein Resource (UniProt). Her team comprises software engineers and bioinformaticians who are responsible for the UniProt, the Gene Ontology Annotation and the Enzyme portal software and database development, and who study novel automatic methods for protein annotation and representation. The team’s user experience analyst coordinates the user request gathering process, which informs the design and development of the web site. Maria’s team is responsible for the maintenance and development of tools for UniProt curation, and works in a fully complementary fashion with Claire O’Donovan’s UniProt Content team to provide essential resources for the biological community, as the databases have become an integral part of the tools researchers use on a daily basis for their work.